Isovitexin(C-8 isoMer)
8-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS: 3681-93-4
Molecular Formula: C21H20O10
Isovitexin(C-8 isoMer) - Names and Identifiers
Isovitexin(C-8 isoMer) - Physico-chemical Properties
| Molecular Formula | C21H20O10 |
| Molar Mass | 432.38 |
| Density | 1.686±0.06 g/cm3(Predicted) |
| Melting Point | 256-257°C |
| Boling Point | 767.7±60.0 °C(Predicted) |
| Specific Rotation(α) | [α]D-18°(c=2，pyridine) |
| Flash Point | 273.1°C |
| Solubility | Soluble in DMSO, chloroform methanol mixed solvent, insoluble in petroleum ether and other solvents |
| Vapor Presure | 8.68E-25mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Yellow |
| BRN | 67796 |
| pKa | 6.27±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.743 |
| MDL | MFCD00017456 |
| Physical and Chemical Properties | Dried and mature fruits from the Rosaceae plant Crateagus pinnatifida |
Isovitexin(C-8 isoMer) - Risk and Safety
| WGK Germany | 3 |
| RTECS | DJ2984000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29389090 |
Isovitexin(C-8 isoMer) - Reference Information
| plant source: | hawthorn |
| plant source | vitexin (vitexin), also known as vitexin, is a natural plant flavonoid glycoside extracted from the leaves of vitex, a verbenaceae plant. It is widely distributed in the leaves and stems of dozens of plants in nature, such as vitex, vines, abacus, hawthorn, ficus microphylla, Alsophila spinulosa leaves, sea sands, black ferns, rustic leaves, mountain red, folium isatidis, etc., the main source of which is the leaves, stems and hawthorn of vitexin plants in the Verbenaceae family. Vitexin has a variety of physiological activities, and has the effects of preventing cancer and anti-tumor, promoting blood circulation and removing blood stasis, regulating qi and veins, anti-inflammatory, antispasmodic, and lowering blood pressure. Clinically, it is mainly used to treat cardiovascular diseases, such as chest obstruction caused by blood stasis, chest tightness and breath, precordial tingling, palpitations and forgetfulness, dizziness and tinnitus, coronary heart disease, angina pectoris, hyperlipidemia, and heart Those with insufficient blood supply to the arteries. In addition, this product can also enhance the function of the adrenal cortex and the phagocytic ability of the monocyte-macrophage system. |
| Chemical composition | Vitum leaves contain volatile oil, of which the main component is β-syringene, followed by syringene, and also contains α-Platycladene, α-and β-pinene, camphor, α-hydrocelone, p-cyclosene, limonene, 1,8-eucalyptoin, etc. It also contains active ingredients such as vitexin, vitexin, and p-hydroxybenzoic acid. |
| determination of content | TLCS method (1) chromatographic conditions: RP-18F254s high-efficiency reversed-phase thin-layer plate, impregnated with 70% tetrahydrofuran aqueous solution (containing 0.1% tetrabutylammonium bromide) for 10min, and dried; Tetrahydrofuran-water (46:54, containing 0.1% tetrabutylammonium bromide); The span is 4.5cm; Inspection under ultraviolet light (254nm). (2) preparation of reference substance solution: proper amounts of vitexin and p-hydroxybenzoic acid are precisely weighed, and anhydrous ethanol is added to prepare a solution containing 0.1mg and 0.05mg per milliliter as the reference substance solution. (3) preparation of sample solution: weigh 5g of each dry and constant weight waxonitum powder (40 mesh) accurately, place it in a Soxhlet extractor, extract it with anhydrous ethanol for 8h, recover the solvent, and use anhydrous ethanol to fix the volume to a 25ml volumetric flask as the sample solution. (4) determination: accurately absorb 2 μl of sample and 2 μl of reference solution, point on the same thin layer plate, expand according to the above chromatographic conditions, take out and dry. According to thin layer scanning method, vitexin λ S = 350nm, p-hydroxybenzoic acid λ S = 258nm; Single wavelength sawtooth scanning by reflection method; SX = 7; Slit: 6mm × 0.2mm. Measure the absorption integral value of the sample and the reference substance, and calculate the content by external standard method. (5) chromatogram fig. 1 is a reversed-phase thin-layer chromatogram of vibrias. s. vibrias produced in Rongcheng; V. vitexin; P. p-hydroxybenzoic acid (6) determination results fig. 2 is the content determination results of samples from different producing areas and different collection periods (n = 3,%) |
| Pharmacological effects | The volatile oil of Ventosa leaf has a significant expectorant effect, can inhibit the cough center and exert an antitussive effect, has an antihistamine effect, and can relieve bronchial smooth muscle spasm and relieve asthma; Ventosa leaf oil emulsion has a significant and long-lasting antihypertensive effect on rabbit blood pressure; Ventosa leaf oil can improve the phagocytic ability of macrophages, it also has the effect of promoting serum protein and regulating immunoglobulin; the oral administration of Vitum leaf oil has a certain sedative and hypnotic effect; the stem and leaf decoction has a significant antibacterial effect on Staphylococcus aureus and Bacillus anthracis, and has a significant antibacterial effect on Escherichia coli, Streptococcus B, Diphtheria, Typhoid bacillus, Pseudomonas aeruginosa and Shigella also have inhibitory effects. vitexin has obvious protective effect on acute myocardial ischemia in rats. The mechanism may be through activating antioxidant enzymes, increasing the activity of SOD and GSH-Px, reducing the damage of excessive oxygen free radicals to tissues, and at the same time resisting the effect of calcium overload, preventing Ca2 + influx through Ca2 + antagonist-like effect, increasing Ca2 + uptake in sarcoplasmic reticulum, reducing cytosolic free Ca2 + concentration, and blocking the aggravation of myocardial cell damage caused by Ca2 + overload, the damage of endothelial cells is reduced, thus reducing the damage of biofilm, ion pump and whole myocardial cells, and finally showing the protective effect on acute myocardial ischemia injury, but the beginning and link of its effect need further study. To sum up, vitexin has a good protective effect on ischemic myocardial injury, which may be related to inhibiting the volume of ischemic myocardial infarction, reducing the viscosity of whole blood and plasma, improving RBC deformability, and inhibiting thrombosis. |
| efficacy and application | 1. for colds, cough and asthma. If you have a cold, you can use it with perilla leaves; it is often used with almonds and perilla. It is now clinically used for chronic bronchitis with good results. 2. used for abdominal pain, heat dampness vomiting and diarrhea. If the heat is wet and vomiting, it can be used with the same asiatica. 3. Used for rubella pruritus, athlete's foot, swelling of beriberi, breast carbuncle, snake bite. Wash the affected area with more pounding or decoction. To cure swelling of beriberi, it can be used with loofah, perilla, calamus, mugwort, etc. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-cancer, antihypertensive, anti-inflammatory and antispasmodic effects. |
Last Update：2024-04-10 22:29:15
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